Funded Projects – Molecular Pathology

The biological role of PSMA for prostate cancer

FWF Austrian Science Fund Grant N° P 32771 – Stand Alone Projects
Principle Investigators: Assoc. Prof. Dr. Gerda Egger, Dr. Raheleh Sheibani Tezerji

The project focuses on the biological function of prostate-specific membrane antigen (PSMA). PSMA is an interesting diagnostic and therapeutic target for prostate cancer, which has been correlated with tumor grade and prognosis. The integrative approach of this project aims to create a multidimensional picture of prostate cancer using machine/deep learning methods in combination with genome-wide proteomic and epigenomic profiling of patient specimen. It is expected that the project will provide novel insights into prostate cancer biology with high translational impact for patient management and development of novel therapeutic options in the future.

Liquid biopsies can be analyzed by artificial intelligence to detect altered DNA fragments in the blood indicating a cancer in the patient.
Photo courtesy of Carolyn Hruban, Johns Hopkins University